SrasV1, Main, Exploration, bibRecord, 002980

Unraveling the complexities of the interferon response during SARS-CoV infection

Identifieur interne : 002980 ( Main/Exploration ); précédent : 002979; suivant : 002981

Unraveling the complexities of the interferon response during SARS-CoV infection

Auteurs : Anna De Lang ; Tracey Baas ; Saskia L. Smits ; Michael G. Katze ; Albert Dme Osterhaus ; Bart L. Haagmans

Source :

Future virology [ 1746-0794 ] ; 2009.

RBID : PMC:2680287

Abstract

Viruses employ different strategies to circumvent the antiviral actions of the innate immune response. SARS coronavirus (SARS-CoV), a virus that causes severe lung damage, encodes an array of proteins able to inhibit induction and signaling of type-I interferons. However, recent studies have demonstrated that interferons are produced during SARS-CoV infection in humans and macaques. Furthermore, nuclear translocation of activated STAT1 and a range of interferon-stimulated genes could be demonstrated in the lungs of SARS-CoV-infected macaques. In line with these observations, plasmacytoid dendritic cells have been shown to produce interferons upon SARS-CoV infection in vitro. Given the pivotal role of interferons during viral infections, (differential) induction of interferons may affect the outcome of the infection. Therefore, the functional implication of interferon production during SARS-CoV infection remains to be re-investigated.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2680287

DOI: 10.2217/17460794.4.1.71
PubMed: 19885368
PubMed Central: 2680287

Affiliations:

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Unraveling the complexities of the interferon response during SARS-CoV infection</title>
<author><name sortKey="De Lang, Anna" sort="De Lang, Anna" uniqKey="De Lang A" first="Anna" last="De Lang">Anna De Lang</name>
</author>
<author><name sortKey="Baas, Tracey" sort="Baas, Tracey" uniqKey="Baas T" first="Tracey" last="Baas">Tracey Baas</name>
</author>
<author><name sortKey="Smits, Saskia L" sort="Smits, Saskia L" uniqKey="Smits S" first="Saskia L" last="Smits">Saskia L. Smits</name>
</author>
<author><name sortKey="Katze, Michael G" sort="Katze, Michael G" uniqKey="Katze M" first="Michael G" last="Katze">Michael G. Katze</name>
</author>
<author><name sortKey="Osterhaus, Albert Dme" sort="Osterhaus, Albert Dme" uniqKey="Osterhaus A" first="Albert Dme" last="Osterhaus">Albert Dme Osterhaus</name>
</author>
<author><name sortKey="Haagmans, Bart L" sort="Haagmans, Bart L" uniqKey="Haagmans B" first="Bart L" last="Haagmans">Bart L. Haagmans</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">19885368</idno>
<idno type="pmc">2680287</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2680287</idno>
<idno type="RBID">PMC:2680287</idno>
<idno type="doi">10.2217/17460794.4.1.71</idno>
<date when="2009">2009</date>
<idno type="wicri:Area/Pmc/Corpus">000C12</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000C12</idno>
<idno type="wicri:Area/Pmc/Curation">000C12</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000C12</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000C57</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000C57</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:19885368</idno>
<idno type="wicri:Area/PubMed/Corpus">001802</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001802</idno>
<idno type="wicri:Area/PubMed/Curation">001802</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001802</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001744</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001744</idno>
<idno type="wicri:Area/Ncbi/Merge">002025</idno>
<idno type="wicri:Area/Ncbi/Curation">002025</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">002025</idno>
<idno type="wicri:doubleKey">1746-0794:2009:De Lang A:unraveling:the:complexities</idno>
<idno type="wicri:Area/Main/Merge">002A21</idno>
<idno type="wicri:Area/Main/Curation">002980</idno>
<idno type="wicri:Area/Main/Exploration">002980</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Unraveling the complexities of the interferon response during SARS-CoV infection</title>
<author><name sortKey="De Lang, Anna" sort="De Lang, Anna" uniqKey="De Lang A" first="Anna" last="De Lang">Anna De Lang</name>
</author>
<author><name sortKey="Baas, Tracey" sort="Baas, Tracey" uniqKey="Baas T" first="Tracey" last="Baas">Tracey Baas</name>
</author>
<author><name sortKey="Smits, Saskia L" sort="Smits, Saskia L" uniqKey="Smits S" first="Saskia L" last="Smits">Saskia L. Smits</name>
</author>
<author><name sortKey="Katze, Michael G" sort="Katze, Michael G" uniqKey="Katze M" first="Michael G" last="Katze">Michael G. Katze</name>
</author>
<author><name sortKey="Osterhaus, Albert Dme" sort="Osterhaus, Albert Dme" uniqKey="Osterhaus A" first="Albert Dme" last="Osterhaus">Albert Dme Osterhaus</name>
</author>
<author><name sortKey="Haagmans, Bart L" sort="Haagmans, Bart L" uniqKey="Haagmans B" first="Bart L" last="Haagmans">Bart L. Haagmans</name>
</author>
</analytic>
<series><title level="j">Future virology</title>
<idno type="ISSN">1746-0794</idno>
<idno type="eISSN">1746-0808</idno>
<imprint><date when="2009">2009</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P1">Viruses employ different strategies to circumvent the antiviral actions of the innate immune response. SARS coronavirus (SARS-CoV), a virus that causes severe lung damage, encodes an array of proteins able to inhibit induction and signaling of type-I interferons. However, recent studies have demonstrated that interferons are produced during SARS-CoV infection in humans and macaques. Furthermore, nuclear translocation of activated STAT1 and a range of interferon-stimulated genes could be demonstrated in the lungs of SARS-CoV-infected macaques. In line with these observations, plasmacytoid dendritic cells have been shown to produce interferons upon SARS-CoV infection <italic>in vitro</italic>
. Given the pivotal role of interferons during viral infections, (differential) induction of interferons may affect the outcome of the infection. Therefore, the functional implication of interferon production during SARS-CoV infection remains to be re-investigated.</p>
</div>
</front>
</TEI>
<affiliations><list></list>
<tree><noCountry><name sortKey="Baas, Tracey" sort="Baas, Tracey" uniqKey="Baas T" first="Tracey" last="Baas">Tracey Baas</name>
<name sortKey="De Lang, Anna" sort="De Lang, Anna" uniqKey="De Lang A" first="Anna" last="De Lang">Anna De Lang</name>
<name sortKey="Haagmans, Bart L" sort="Haagmans, Bart L" uniqKey="Haagmans B" first="Bart L" last="Haagmans">Bart L. Haagmans</name>
<name sortKey="Katze, Michael G" sort="Katze, Michael G" uniqKey="Katze M" first="Michael G" last="Katze">Michael G. Katze</name>
<name sortKey="Osterhaus, Albert Dme" sort="Osterhaus, Albert Dme" uniqKey="Osterhaus A" first="Albert Dme" last="Osterhaus">Albert Dme Osterhaus</name>
<name sortKey="Smits, Saskia L" sort="Smits, Saskia L" uniqKey="Smits S" first="Saskia L" last="Smits">Saskia L. Smits</name>
</noCountry>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002980 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002980 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    SrasV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     PMC:2680287
   |texte=   Unraveling the complexities of the interferon response during SARS-CoV infection
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:19885368" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a SrasV1

This area was generated with Dilib version V0.6.33.
Data generation: Tue Apr 28 14:49:16 2020. Site generation: Sat Mar 27 22:06:49 2021

Serveur d'exploration SRAS

Unraveling the complexities of the interferon response during SARS-CoV infection

Unraveling the complexities of the interferon response during SARS-CoV infection

Source :

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration SRAS
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.